The Role: Generate is seeking a Senior Director, Scientific Project Lead, Cardio-Renal-Metabolic to lead complex, cross-functional scientific programs from concept and early discovery through preclinical proof-of-concept, contribute to translational and early development strategy, and manage and develop scientific talent. This role combines formal people management with broad cross-functional leadership across research, platform, translational, development, and portfolio functions. Working closely with functional , business and technical leaders, project managers , and senior and executive stakeholders, the Scientific Project Lead will bring scientific judgment in therapeutic discovery , strategic program leadership, and operational rigor to align multidisciplinary teams, guide key decisions, represent programs in governance forums, and contribute to portfolio prioritization. Here's how you will contribute: - Lead complex programs from concept and early discovery through preclinical proof-of-concept, with accountability for scientific strategy, execution quality, team effectiveness, risk management, and stage-gate readiness. - Develop and maintain integrated program strategies and plans that align scientific objectives , timelines, and resourcing. - Set scientific program direction, identify and advance therapeutic opportunities and target proposals by integrating biology, Generate’s differentiated platform capabilities, internal and external evidence, translational and clinical rationale, and competitive intelligence. - Facilitate cross-functional discussions, resolve divergent perspectives, make clear recommendations, own key scientific decisions within the project team structure, and drive timely go/no-go recommendations. - Drive execution across wet lab , computational, platform , and translational workstreams, ensuring scientific rigor, reproducibility, strong documentation, and high-quality data packages. - Develop resource plans and budget assumptions, anticipate strategic inflection points, and proactively resolve risks, gaps, and cross-functional dependencies. - Build effective operating mechanisms for program planning, governance preparation, risk tracking, decision-making, and cross-functional accountability. - Manage, coach, and develop direct reports through clear objectives , regular feedback, performance management, and career development; mentor cross-functional team members in partnership with their functional managers. - Set clear expectations and foster a high-performing team culture grounded in scientific rigor, accountability, transparency, urgency, collaboration, and constructive challenge. The Ideal Candidate will have: - PhD, MD, or MD/PhD in the life sciences or another discipline relevant to therapeutic discovery and development. - 12+ years of r elevant experience in biotech, pharma, academia, or a related scientific environment. - Experience identifying , evaluating, and advancing therapeutic targets and programs in cardio-renal-metabolic diseases or related areas , including relevant in vitro and in vivo preclinical models and translational considerations such as biomarkers and PK/PD. - Demonstrated success advancing complex programs across discovery and translational stages, including stage-gate reviews, prioritization decisions, and early development planning. - Experience managing and developing scientists or other technical professionals, together with a strong record of leading multidisciplinary teams through influence. - Strong scientific grounding in biology, experimental design, data interpretation, and synthesis across multiple technical domains. - A track record of identifying, evaluating, and advancing novel targets or therapeutic opportunities with strong biological and translational rationale. - Experience shaping program strategy, influencing senior stakeholders, and driving decisions in matrixed environments without relying solely on direct line authority. - Ability to synthesize complex scientific issues, make sound recommendations with incomplete information, navigate scientific and resource tradeoffs, and communicate clearly in governance settings. - Strong operational leadership, learning agility, intellectual curiosity, and comfort working in ambiguous and evolving environments, with a practical approach to solving problems and unblocking teams. Preferred Qualifications - Experience with protein therapeutics and related modalities, including peptides and conjugate-based approaches. - Familiarity with computational protein design, machine learning-enabled discovery, or platform-scale biological systems. - Familiarity with IND-enabling studies and early clinical development. - Experience working effectively with consultants, CROs, and other external partners. - Comfort using LLM-enabled tools and emerging agentic workflows to support scientific planning, analysis, and execution. Who Will Love This Job: - A biomedical scientist who enjoys identifying novel targets and turning early ideas into well-defined therapeutic opportunities. - A scientifically grounded leader energized by complex programs, consequential decisions, and incomplete information. - An entrepreneurial, hands-on problem solver who thrives at the interface of biology, platform technologies, translational science, and portfolio strategy. - A matrix leader who builds trust, sets a high bar, and aligns strong cross-functional partners through influence. - A people leader who enjoys developing talent while building resilient, collaborative, and high-performing teams. About Generate Biomedicines We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines. Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation. At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors. Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto. #LI-RT1 Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Per Year Salary Range $210,000 — $300,000 USD